Venetoclax does not impair activated T-cell proliferation

Retinal pericytes inhibit activated T cell proliferation.

PURPOSE To test the hypothesis that retinal pericytes (RPCs) are immunosuppressive; therefore, their loss of function under hyperglycemic conditions favors retinal inflammation and contributes to the pathogenesis of diabetic retinopathy (DR). METHODS Isolated mouse and human RPCs were tested in T cell function assays to evaluate their capability of inhibiting T cell responses. To elucidate th...

Childhood morphea does not impair self-perception

Methods We studied 19 patients attending our Department (68,4% female, median age 13,6 yrs). The Childhood Health Assessment Questionnaire (CHAQ) was administered to all patients. The CHAQ is a disease specific instrument selected because of its widespread use in the pediatric rheumatology literature and ease of administration. The CHAQ measures functional ability in eight activities of daily l...

High Fat Diet Inhibits Dendritic Cell and T Cell Response to Allergens but Does Not Impair Inhalational Respiratory Tolerance

The incidence of obesity has risen to epidemic proportions in recent decades, most commonly attributed to an increasingly sedentary lifestyle, and a 'western' diet high in fat and low in fibre. Although non-allergic asthma is a well-established co-morbidity of obesity, the influence of obesity on allergic asthma is still under debate. Allergic asthma is thought to result from impaired tolerance...

Inhibition of mitogen-activated protein kinase kinase does not impair primary activation of human platelets.

Mitogen-activated protein kinases (MAPKs), a family of protein serine/threonine kinases regulating cell growth and differentiation, are activated by a dual-specificity kinase through phosphorylation at threonine and tyrosine. We used a recently described selective inhibitor of the p42/p44mapk-activating enzyme, PD 98059 [2-(2'-amino-3'-methoxyphenyl)-oxanaphthalen-4-one], to investigate the rol...

Lymphopenia for T Cell Proliferation in Moderate Elevated IL-7 Availability Does Not Account